Cognitive inflexibility (high perseveration-proneness) moderated this effect in Group HC. Moderator/mediator effects of trait and neuropsychological factors and GD severity (South Oaks Gambling Screen SOGS) were explored via covariance.ĪMPH led to an escalation in risky POS over trial blocks in both groups, regardless of pre-treatment. Pre-treatment (antagonist, placebo) was manipulated within-participants and counterbalanced over sessions for Slots and AMPH test phases. Antagonist Group (HAL, FLU) was manipulated between-participants. Participants attended a pre-experimental baseline session and 4 test sessions. If DA mediates these effects, outcomes will vary with pre-treatment. Slots and AMPH will each increase risk-taking based on fewer (less probable) possible outcomes selected (POS) and poorer net monetary outcomes (NMO gains minus losses) on the GDT, with stronger effects in Group GD. The role of dopamine (DA) was assessed by pre-treating participants with the D2 receptor (D2R)-preferring antagonist, haloperidol (HAL 3-mg) or mixed D1R-D2R antagonist, fluphenazine (FLU 3-mg).

To investigate effects of slot machine gambling (Slots) and d-amphetamine (AMPH 20 mg) on risk-taking in people with GD and healthy controls (HCs) (n = 30/group). No research appears to have assessed effects of gambling-specific priming manipulations or the pharmacological basis of such effects on the GDT. The Game of Dice Task (GDT) captures probabilistic risk-taking, which is an important feature of addictions and integral to gambling disorder (GD).

What is the slot machine effect